DISULFIDE SCRAMBLING IN SUPEROXIDE DISMUTASE 1 REDUCES ITS CYTOTOXIC EFFECT IN CULTURED CELLS AND PROMOTES PROTEIN AGGREGATION.

Disulfide scrambling in superoxide dismutase 1 reduces its cytotoxic effect in cultured cells and promotes protein aggregation.

Mutations in the gene coding for superoxide dismutase 1 (SOD1) are associated with familiar forms of the neurodegenerative disease amyotrophic lateral sclerosis (ALS).These mutations are believed to result in a "gain of toxic function", leading to neuronal degeneration.The exact mechanism is still unknown, but misfolding/aggregation events are gene

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Housing Density and Ecosystem Function: Comparing the Impacts of Rural, Exurban, and Suburban Densities on Fire Hazard, Water Availability, and House and Road Distance Effects

Many amenity-rich regions are experiencing rapid land-use change through low-density residential development or exurbanization.Those same natural-resource amenities that attracted migration are often degraded by housing growth and associated development.This study examines the impacts of exurbanization on three ecosystem Extras indicators (fire haz

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